Expression and regulation of murine SPINK12, a potential orthologue of human LEKTI2
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378050%3A_____%2F11%3A00371299" target="_blank" >RIV/68378050:_____/11:00371299 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1111/j.1600-0625.2011.01355.x" target="_blank" >http://dx.doi.org/10.1111/j.1600-0625.2011.01355.x</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1111/j.1600-0625.2011.01355.x" target="_blank" >10.1111/j.1600-0625.2011.01355.x</a>
Alternative languages
Result language
angličtina
Original language name
Expression and regulation of murine SPINK12, a potential orthologue of human LEKTI2
Original language description
We describe expression and regulation of murine SPINK12, potential orthologue of human LEKTI2. Its expression was analysed by RT-PCR and immunohistochemistry revealing organ-specific pattern with high level of expression in epidermis and several epithelia including stomach, kidney and uterus. mSPINK12 expression in skin epidermis at footpads, where stratification is markedly pronounced, was several folds higher than in the abdominal epidermis. mSPINK12 mRNA levels were not affected by any cytokines tested while treatment of primary murine keratinocytes with the combination of calcium and sorbitol resulted in a strong increase in its mRNA. mspink12 seems especially expressed in the epidermal areas with thick skin and its regulation generally responds todifferentiation signals. mrSPINK12 shows inhibitory activity against murine keratinocyte-derived trypsin-like proteolytic activity and appears orthologous to human LEKTI2, with possible role in regulation of epithelial cell functions.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EB - Genetics and molecular biology
OECD FORD branch
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Result continuities
Project
<a href="/en/project/GC301%2F08%2FJ053" target="_blank" >GC301/08/J053: Mouse models for investigation of biological functions of novel Kazal-type protease inhibitors LEKTI-2 and LEKTI-3</a><br>
Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)
Others
Publication year
2011
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Experimental Dermatology
ISSN
0906-6705
e-ISSN
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Volume of the periodical
20
Issue of the periodical within the volume
11
Country of publishing house
US - UNITED STATES
Number of pages
6
Pages from-to
905-910
UT code for WoS article
000296616200006
EID of the result in the Scopus database
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