Checkpoint control and cancer
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378050%3A_____%2F12%3A00387880" target="_blank" >RIV/68378050:_____/12:00387880 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1038/onc.2011.451" target="_blank" >http://dx.doi.org/10.1038/onc.2011.451</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1038/onc.2011.451" target="_blank" >10.1038/onc.2011.451</a>
Alternative languages
Result language
angličtina
Original language name
Checkpoint control and cancer
Original language description
DNA-damaging therapies represent the most frequently used non-surgical anticancer strategies in the treatment of human tumors. These therapies can kill tumor cells, but at the same time they can be particularly damaging and mutagenic to healthy tissues.The efficacy of DNA-damaging treatments can be improved if tumor cell death is selectively enhanced, and the recent application of poly-(ADP-ribose) polymerase inhibitors in BRCA1/2-deficient tumors is a successful example of this. DNA damage is known totrigger cell-cycle arrest through activation of DNA-damage checkpoints. This arrest can be reversed once the damage has been repaired, but irreparable damage can promote apoptosis or senescence. Alternatively, cells can reenter the cell cycle before repair has been completed, giving rise to mutations. In this review we discuss the mechanisms involved in the activation and inactivation of DNA-damage checkpoints, and how the transition from arrest and cell-cycle re-entry is controlled. In
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EB - Genetics and molecular biology
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2012
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Oncogene
ISSN
0950-9232
e-ISSN
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Volume of the periodical
31
Issue of the periodical within the volume
21
Country of publishing house
GB - UNITED KINGDOM
Number of pages
13
Pages from-to
2601-2613
UT code for WoS article
000304523500001
EID of the result in the Scopus database
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