Phenotyping of circulating CD8(+) T cell subsets in human cutaneous leishmaniasis

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378050%3A_____%2F12%3A00389981" target="_blank" >RIV/68378050:_____/12:00389981 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1016/j.micinf.2012.02.006" target="_blank" >http://dx.doi.org/10.1016/j.micinf.2012.02.006</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.micinf.2012.02.006" target="_blank" >10.1016/j.micinf.2012.02.006</a>

Result language
angličtina
Original language name
Phenotyping of circulating CD8(+) T cell subsets in human cutaneous leishmaniasis
Original language description
Recovery from CL is usually accompanied with long-lasting protection and induction of strong immune response. The phenotypes, generation and maintenance of central (=T-CM) and effector (=T-EM) memory T cell subsets in human leishmaniasis are not well known. Profile of T cell subsets were analyzed on peripheral CD8(+) T cells from volunteers with history of cutaneous leishmaniasis (HCL). In HCL and control groups, mean frequencies of CCR7(+)CD45RA(+)CD8(+) naive and CCR7(-)CD45RA(-)CD8(+) T-EM cells werehigher than other subsets before culture, but after stimulation with soluble Leishmania antigen, the frequency of naive T cells was significantly decreased and the frequency of T-EM cells was significantly increased. T-EM phenotype composed the highestportion of proliferating Carboxy Fluorescein diacetate Succinimidyl Ester (CFSE)-dim population which was significantly higher in HCL volunteers than in control group. Stimulation of isolated CD8(+) memory T cells, but not naive T cells,
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EB - Genetics and molecular biology
OECD FORD branch
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Project
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Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2012
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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