Mitochondrial Dysfunction in Gliomas
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378050%3A_____%2F13%3A00423057" target="_blank" >RIV/68378050:_____/13:00423057 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1016/j.spen.2013.09.003" target="_blank" >http://dx.doi.org/10.1016/j.spen.2013.09.003</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.spen.2013.09.003" target="_blank" >10.1016/j.spen.2013.09.003</a>
Alternative languages
Result language
angličtina
Original language name
Mitochondrial Dysfunction in Gliomas
Original language description
Mitochondrial (mt) dysfunction in gliomas has been linked to abnormalities of mt energy metabolism, marked by a metabolic shift from oxidative phosphorylation to glycolysis ("Warburg effect"), disturbances in mt membrane potential regulation and apoptotic signaling, as well as to somatic mutations involving the Krebs cycle enzyme isocitrate dehydrogenase. Evolving biological concepts with potential therapeutic implications include interaction between microtubule proteins and mitochondria (mt) in the control of closure of voltage-dependent anion channels and in the regulation of mt dynamics and the mt-endoplasmic reticulum network. The cytoskeletal protein beta III-tubulin, which is overexpressed in malignant gliomas, has emerged as a prosurvival factorassociated in part with nit and also as a marker of chemoresistance. Mt-targeted therapeutic strategies that are discussed include the following: (1) metabolic modulation with emphasis on dichloroacetate, a pyruvate dehydrogenase kinase
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EB - Genetics and molecular biology
OECD FORD branch
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Result continuities
Project
<a href="/en/project/LH12050" target="_blank" >LH12050: Regulation of microtubule formation in brain cancer cells</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Seminars in Pediatric Neurology
ISSN
1071-9091
e-ISSN
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Volume of the periodical
20
Issue of the periodical within the volume
3
Country of publishing house
US - UNITED STATES
Number of pages
12
Pages from-to
216-227
UT code for WoS article
000328262000007
EID of the result in the Scopus database
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