Molecular analysis of the TGF-beta controlled gene expression program in chicken embryo dermal myofibroblasts

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378050%3A_____%2F13%3A00423219" target="_blank" >RIV/68378050:_____/13:00423219 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1016/j.gene.2012.10.069" target="_blank" >http://dx.doi.org/10.1016/j.gene.2012.10.069</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.gene.2012.10.069" target="_blank" >10.1016/j.gene.2012.10.069</a>

Result language
angličtina
Original language name
Molecular analysis of the TGF-beta controlled gene expression program in chicken embryo dermal myofibroblasts
Original language description
The myofibroblast is a mesenchymal cell characterized by synthesis of the extracellular matrix, plus contractile and secretory activities. Myofibroblasts participate in physiological tissue repair, but can also cause devastating fibrosis. They are present in the tumor stroma of carcinomas and contribute to tumor growth and spreading. As myofibroblasts derive from various cell types and appear in a variety of tissues, there is marked variability in their phenotype. As regulatory mechanism of wound healing are likely conserved among vertebrates, detailed knowledge of these mechanisms in more distant species will help to distinguish general from specific phenomena. To provide this as yet missing comparison, we analyzed the impact of the chemical inhibition of TGF-beta signaling on gene expression in chicken embryo dermal myofibroblasts. We revealed genes previously reported in mammalian systems (e.g. SPON2, ASPN, COMP, LUM, HAS2, IL6, CXCL12,VEGFA) as well as novel TGF-beta dependent gene
Czech name
—
Czech description
—

Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EB - Genetics and molecular biology
OECD FORD branch
—

Project
<a href="/en/project/KAN200520801" target="_blank" >KAN200520801: Targeted expression and transport of bioactive molecules</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Similar results(10)