Emerging microtubule targets in glioma therapy
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378050%3A_____%2F15%3A00455817" target="_blank" >RIV/68378050:_____/15:00455817 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1016/j.spen.2015.03.009" target="_blank" >http://dx.doi.org/10.1016/j.spen.2015.03.009</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.spen.2015.03.009" target="_blank" >10.1016/j.spen.2015.03.009</a>
Alternative languages
Result language
angličtina
Original language name
Emerging microtubule targets in glioma therapy
Original language description
Major advances in the genomics and epigenomics of diffuse gliomas and glioblastoma to date have not been translated into effective therapy, necessitating pursuit of alternative treatment approaches for these therapeutically challenging tumors. Current knowledge of microtubules in cancer and the development of new microtubule-based treatment strategies for high-grade gliomas are the topic in this review article. Discussed are cellular, molecular, and pharmacologic aspects of the microtubule cytoskeletonunderlying mitosis and interactions with other cellular partners involved in cell cycle progression, directional cell migration, and tumor invasion. Special focus is placed on (1) the aberrant overexpression of beta III-tubulin, a survival factor associated with hypoxic tumor microenvironment and dynamic instability of microtubules; (2) the ectopic overexpression of gamma-tubulin, which in addition to its conventional role as a microtubule-nucleating protein has recently emerged as a tra
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EB - Genetics and molecular biology
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Seminars in Pediatric Neurology
ISSN
1071-9091
e-ISSN
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Volume of the periodical
22
Issue of the periodical within the volume
1
Country of publishing house
US - UNITED STATES
Number of pages
23
Pages from-to
49-72
UT code for WoS article
000355021000009
EID of the result in the Scopus database
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