The Nodal signaling pathway controls left-right asymmetric development in amphioxus

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378050%3A_____%2F15%3A00455872" target="_blank" >RIV/68378050:_____/15:00455872 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1186/2041-9139-6-5" target="_blank" >http://dx.doi.org/10.1186/2041-9139-6-5</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1186/2041-9139-6-5" target="_blank" >10.1186/2041-9139-6-5</a>

Result language
angličtina
Original language name
The Nodal signaling pathway controls left-right asymmetric development in amphioxus
Original language description
Background: Nodal is an important determinant of the left-right (LR) body axis in bilaterians, specifying the right side in protostomes and non-chordate deuterostomes as opposed to the left side in chordates. Amphioxus represents an early-branching chordate group, rendering it especially useful for studying the character states that predate the origin of vertebrates. However, its anatomy, involving offset arrangement of axial structures, marked asymmetry of the oropharyngeal region, and, most notably, amouth positioned on the left side, contrasts with the symmetric arrangement of the corresponding regions in other chordates.nnResults: We show that the Nodal signaling pathway acts to specify the LR axis in the cephalochordate amphioxus in a similar way as in vertebrates. At early neurula stages, Nodal switches from initial bilateral to the left-sided expression and subsequently specifies the left embryonic side. Perturbation of Nodal signaling with small chemical inhibitors (SB505124
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EB - Genetics and molecular biology
OECD FORD branch
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Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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