Left-right asymmetry specification in amphioxus: review and prospects

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378050%3A_____%2F17%3A00502671" target="_blank" >RIV/68378050:_____/17:00502671 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.1387/ijdb.170251vs" target="_blank" >http://dx.doi.org/10.1387/ijdb.170251vs</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1387/ijdb.170251vs" target="_blank" >10.1387/ijdb.170251vs</a>

Result language

angličtina

Original language name

Left-right asymmetry specification in amphioxus: review and prospects

Original language description

Extant bilaterally symmetrical animals usually show asymmetry in the arrangement of their inner organs. However, the exaggerated left`-right (LR) asymmetry in amphioxus represents a true peculiarity among them. The amphioxus larva shows completely disparate fates of left and right body sides, so that organs associated with pharynx are either positioned exclusively on the left or on the right side. Moreover, segmented paraxial structures such as muscle blocks and their neuronal innervation show offset arrangement between the sides making it difficult to propose any explanation or adaptivity to larval and adult life. First LR asymmetries can be traced back to an early embryonic period when morphological asymmetries are preceded by molecular asymmetries driven by the action of the Nodal signaling pathway. This review sums up recent advances in understanding LR asymmetry specification in amphioxus and proposes upstream events that may regulate asymmetric Nodal signaling. These events include the presence of the vertebrate-like LR organizer and a cilia-driven fluid flow that may be involved in the breaking of bilateral symmetry. The upstream pathways comprising the ion flux, Delta/Notch, Wnt/beta-catenin and Wnt/PCP are hypothesized to regulate both formation of the LR organizer and expression of the downstream Nodal signaling pathway genes. These suggestions are in line with what we know from vertebrate and ambulacrarian LR axis specification and are directly testable by experimental manipulations. Thanks to the phylogenetic position of amphioxus, the proposed mechanisms may be helpful in understanding the evolution of LR axis specification across deuterostomes.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

10605 - Developmental biology

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2017

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

International Journal of Developmental Biology

ISSN

0214-6282

e-ISSN

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Volume of the periodical

61

Issue of the periodical within the volume

10-12

Country of publishing house

ES - SPAIN

Number of pages

10

Pages from-to

611-620

UT code for WoS article

000418431600006

EID of the result in the Scopus database

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