Parasite Cathepsin D-Like Peptidases and Their Relevance as Therapeutic Targets
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378050%3A_____%2F16%3A00463316" target="_blank" >RIV/68378050:_____/16:00463316 - isvavai.cz</a>
Alternative codes found
RIV/60077344:_____/16:00463316 RIV/61388963:_____/16:00471803
Result on the web
<a href="http://dx.doi.org/10.1016/j.pt.2016.05.015" target="_blank" >http://dx.doi.org/10.1016/j.pt.2016.05.015</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.pt.2016.05.015" target="_blank" >10.1016/j.pt.2016.05.015</a>
Alternative languages
Result language
angličtina
Original language name
Parasite Cathepsin D-Like Peptidases and Their Relevance as Therapeutic Targets
Original language description
Inhibition of aspartic cathepsin D-like peptidases (APDs) has been often discussed as an antiparasite intervention strategy. APDs have been considered as virulence factors of Trypanosoma cruzi and Leishmania spp., and have been demonstrated to have important roles in protein trafficking mechanisms of apicomplexan parasites. APDs also initiate blood digestion as components of multienzyme proteolytic complexes in malaria, platyhelminths, nematodes, and ticks. Increasing DNA and RNA sequencing data indicate that parasites express multiple APD isoenzymes of various functions that can now be specifically evaluated using new functional-genomic and biochemical tools, from which we can further assess the potential of APDs as targets for novel effective intervention strategies against parasitic diseases that still pose an alarming threat to mankind.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
GJ - Diseases and animal vermin, veterinary medicine
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2016
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Trends in Parasitology
ISSN
1471-4922
e-ISSN
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Volume of the periodical
32
Issue of the periodical within the volume
9
Country of publishing house
GB - UNITED KINGDOM
Number of pages
16
Pages from-to
708-723
UT code for WoS article
000383302000008
EID of the result in the Scopus database
2-s2.0-84991672014