Metalloproteinases in liver fibrosis: current insights

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378050%3A_____%2F17%3A00540344" target="_blank" >RIV/68378050:_____/17:00540344 - isvavai.cz</a>

Result on the web

<a href="https://www.dovepress.com/metalloproteinases-in-liver-fibrosis-current-insights-peer-reviewed-article-MNM" target="_blank" >https://www.dovepress.com/metalloproteinases-in-liver-fibrosis-current-insights-peer-reviewed-article-MNM</a>

DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Metalloproteinases in liver fibrosis: current insights

Original language description

Liver fibrosis is defined by excessive deposition of extracellular matrix. The fibrotic conditions result from the imbalance between synthesis and deposition of fibrous tissues and decomposition of these matrix proteins. This process can be reversed as a regular part of the healing process after hepatic damage or can become chronic. When the protein matrix synthesis predominates and the decomposition is suppressed, fibrosis will progress into irreversible cirrhosis or steatosis. Among the molecular players involved in fibrotic liver diseases, metalloproteinases of matrix metalloproteinase (MMP) and a disintegrin and metalloproteinase (ADAM) families are critical in the development of liver fibrosis and its resolution. Previously, MMPs were recognized as extracellular matrix degrading enzymes. Currently, they are also known as mediators in a variety of processes related to immunity and tissue repair. In this article, we have reviewed the models of liver fibrosis and findings on MMPs and ADAMs in hepatic fibrosis conditions.

Czech name

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Czech description

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Type

J_ost - Miscellaneous article in a specialist periodical

CEP classification

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OECD FORD branch

10603 - Genetics and heredity (medical genetics to be 3)

Project

<a href="/en/project/LQ1604" target="_blank" >LQ1604: BIOCEV: from Fundamental to Applied Research</a><br>

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2017

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Metalloproteinases In Medicine

ISSN

2324-2027

e-ISSN

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Volume of the periodical

4

Issue of the periodical within the volume

February

Country of publishing house

GB - UNITED KINGDOM

Number of pages

11

Pages from-to

25-35

UT code for WoS article

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EID of the result in the Scopus database

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