A novel conditional Aire allele enables cell-specific ablation of the immune tolerance regulator Aire

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378050%3A_____%2F18%3A00496067" target="_blank" >RIV/68378050:_____/18:00496067 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11310/18:10390005
Result on the web
<a href="http://dx.doi.org/10.1002/eji.201747267" target="_blank" >http://dx.doi.org/10.1002/eji.201747267</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/eji.201747267" target="_blank" >10.1002/eji.201747267</a>

Result language
angličtina
Original language name
A novel conditional Aire allele enables cell-specific ablation of the immune tolerance regulator Aire
Original language description
Medullary thymic epithelial cell (mTEC)‐restricted expression of autoimmune regulator (Aire) nis essential for establishment of immune tolerance. Recently, Aire was also shown to be nexpressed in cells of hematopietic and reproductive lineages. Thus, the generation of Aire nfl/fl mouse strain enables the investigation of the cell‐specific function of Aire.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
30102 - Immunology

Project
<a href="/en/project/GA16-26143S" target="_blank" >GA16-26143S: Extrathymic Aire-expressing cells in peripheral T-cell tolerance</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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