AIRE in Male Fertility: A New Hypothesis

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378050%3A_____%2F22%3A00566168" target="_blank" >RIV/68378050:_____/22:00566168 - isvavai.cz</a>

Result on the web

<a href="https://www.mdpi.com/2073-4409/11/19/3168" target="_blank" >https://www.mdpi.com/2073-4409/11/19/3168</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3390/cells11193168" target="_blank" >10.3390/cells11193168</a>

Result language

angličtina

Original language name

AIRE in Male Fertility: A New Hypothesis

Original language description

Male infertility affects approximately 14% of all European men, of which similar to 44% are characterized as idiopathic. There is an urgency to identify the factors that affect male fertility. One such factor, Autoimmune Regulator (AIRE), a protein found in the thymus, has been studied in the context of central tolerance functioning as a nuclear transcription modulator, responsible for the expression of tissue-restricted antigens in specialized thymic cells that prevent autoimmunity. While its expression in the testes remains enigmatic, we recently observed that sterility in mice correlates with the absence of Aire in the testes, regardless of the deficient expression in medullary thymic epithelial cells or cells of the hematopoietic system. By assessing the Aire transcript levels, we discovered that Sertoli cells are the exclusive source of Aire in the testes, where it most likely plays a non-immune role, suggesting an unknown mechanism by which testicular Aire regulates fertility. Here, we discuss these results in the context of previous reports which have suggested that infertility observed in Aire deficient mice is of an autoimmune aetiology. We present an alternative point of view for the role of Aire in testes in respect to fertility altering the perspective of how Aire's function in the testes is currently perceived.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

10601 - Cell biology

Project

<a href="/en/project/GA20-30350S" target="_blank" >GA20-30350S: Heterogeneity and the role of thymic immune cells in establishment of tolerance</a><br>

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2022

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Cells

ISSN

2073-4409

e-ISSN

2073-4409

Volume of the periodical

11

Issue of the periodical within the volume

19

Country of publishing house

CH - SWITZERLAND

Number of pages

10

Pages from-to

3168

UT code for WoS article

000866852800001

EID of the result in the Scopus database

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