Polymer cancerostatics targeted by recombinant antibody fragments to GD2-positive tumor cells
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378050%3A_____%2F19%3A00499714" target="_blank" >RIV/68378050:_____/19:00499714 - isvavai.cz</a>
Alternative codes found
RIV/61389013:_____/19:00499714
Result on the web
<a href="https://pubs.acs.org/doi/10.1021/acs.biomac.8b01616" target="_blank" >https://pubs.acs.org/doi/10.1021/acs.biomac.8b01616</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1021/acs.biomac.8b01616" target="_blank" >10.1021/acs.biomac.8b01616</a>
Alternative languages
Result language
angličtina
Original language name
Polymer cancerostatics targeted by recombinant antibody fragments to GD2-positive tumor cells
Original language description
A water-soluble polymer cancerostatic actively targeted against cancer cells expressing a disialoganglioside antigen GD2 was designed, synthesized and characterized. A polymer conjugate of an antitumor drug doxorubicin with a N-(2-hydroxypropyl)methacrylamide-based copolymer was specifically targeted against GD2 antigen-positive tumor cells using a recombinant single chain fragment (scFv) of an anti-GD2 monoclonal antibody. The targeting protein ligand was attached to the polymer–drug conjugate either via a covalent bond between the amino groups of the protein using a traditional nonspecific aminolytic reaction with a reactive polymer precursor or via a noncovalent but highly specific interaction between bungarotoxin covalently linked to the polymer and the recombinant scFv modified with a C-terminal bungarotoxin-binding peptide. The GD2 antigen binding activity and GD2-specific cytotoxicity of the targeted noncovalent polymer–scFv complex proved to be superior to the covalent polymer–scFv conjugate.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10609 - Biochemical research methods
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Biomacromolecules
ISSN
1525-7797
e-ISSN
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Volume of the periodical
20
Issue of the periodical within the volume
1
Country of publishing house
US - UNITED STATES
Number of pages
10
Pages from-to
412-421
UT code for WoS article
000456349600036
EID of the result in the Scopus database
2-s2.0-85059898451