Tetraspanins in the regulation of mast cell function

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378050%3A_____%2F20%3A00539685" target="_blank" >RIV/68378050:_____/20:00539685 - isvavai.cz</a>

Result on the web

<a href="https://link.springer.com/article/10.1007/s00430-020-00679-x" target="_blank" >https://link.springer.com/article/10.1007/s00430-020-00679-x</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s00430-020-00679-x" target="_blank" >10.1007/s00430-020-00679-x</a>

Result language

angličtina

Original language name

Tetraspanins in the regulation of mast cell function

Original language description

Mast cells (MCs) are long-living immune cells highly specialized in the storage and release of different biologically active compounds and are involved in the regulation of innate and adaptive immunity. MC degranulation and replacement of MC granules are accompanied by active membrane remodelling. Tetraspanins represent an evolutionary conserved family of transmembrane proteins. By interacting with lipids and other membrane and intracellular proteins, they are involved in organisation of membrane protein complexes and act as 'molecular facilitators' connecting extracellular and cytoplasmic signaling elements. MCs express different tetraspanins and MC degranulation is accompanied by changes in membrane organisation. Therefore, tetraspanins are very likely involved in the regulation of MC exocytosis and membrane reorganisation after degranulation. Antiviral response and production of exosomes are further aspects of MC function characterized by dynamic changes of membrane organization. In this review, we pay a particular attention to tetraspanin gene expression in different human and murine MC populations, discuss tetraspanin involvement in regulation of key MC signaling complexes, and analyze the potential contribution of tetraspanins to MC antiviral response and exosome production. In-depth knowledge of tetraspanin-mediated molecular mechanisms involved in different aspects of the regulation of MC response will be beneficial for patients with allergies, characterized by overwhelming MC reactions.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30102 - Immunology

Project

<a href="/en/project/GA20-16481S" target="_blank" >GA20-16481S: The role of tetraspanin CD53 in mast cell biology</a><br>

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2020

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Medical Microbiology and Immunology

ISSN

0300-8584

e-ISSN

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Volume of the periodical

209

Issue of the periodical within the volume

4

Country of publishing house

US - UNITED STATES

Number of pages

13

Pages from-to

531-543

UT code for WoS article

000538922000001

EID of the result in the Scopus database

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