Four novel genes associated with longevity found in Cane corso purebred dogs

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378050%3A_____%2F22%3A00557828" target="_blank" >RIV/68378050:_____/22:00557828 - isvavai.cz</a>
Result on the web
<a href="https://bmcvetres.biomedcentral.com/articles/10.1186/s12917-022-03290-9" target="_blank" >https://bmcvetres.biomedcentral.com/articles/10.1186/s12917-022-03290-9</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1186/s12917-022-03290-9" target="_blank" >10.1186/s12917-022-03290-9</a>

Result language
angličtina
Original language name
Four novel genes associated with longevity found in Cane corso purebred dogs
Original language description
Background Longevity-related genes have been found in several animal species as well as in humans. The goal of this study was to perform genetic analysis of long-lived Cane corso dogs with the aim to find genes that are associated with longevity. Results SNPs with particular nucleotides were significantly overrepresented in long-lived dogs in four genes, TDRP, MC2R, FBXO25 and FBXL21. In FBXL21, the longevity-associated SNP localises to the exon. In the FBXL21 protein, tryptophan in long-lived dogs replaced arginine present in reference dogs. Conclusions Four SNPs associated with longevity in dogs were identified using GWAS and validated by DNA sequencing. We conclude that genes TDRP, MC2R, FBXO25 and FBXL21 are associated with longevity in Cane corso dogs.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10607 - Virology

Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2022
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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