Three new genes associated with longevity in the European Bison

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378050%3A_____%2F22%3A00560533" target="_blank" >RIV/68378050:_____/22:00560533 - isvavai.cz</a>
Result on the web
<a href="https://www.sciencedirect.com/science/article/pii/S2451943X22000370?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S2451943X22000370?via%3Dihub</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.vas.2022.100266" target="_blank" >10.1016/j.vas.2022.100266</a>

Result language
angličtina
Original language name
Three new genes associated with longevity in the European Bison
Original language description
Longevity-related genes have been found in humans, mice, dogs and in several other animal species. The goal of this study was to perform genetic analysis of long-lived European bisons with the aim to find genes that are associated with longevity using GWAS and further sequencing of a wider sample panel. European bison has a unique history of near extinction and the recovery of the species from just a few founder individuals. Together with the short medium lifespan, the expected genetic homogeneity makes bison a suitable model for studying longevity. Particular single nucleotide polymorphisms within three genes, BCKDHB, FER1L6 and SERPINI2, were found significantly overrepresented in long-lived European bisons. In SERPINI2, the longevity-associated single nucleotide polymorphism localizes to an exon. In the protein encoded by the SERPINI2 gene, amino acid leucine present in the reference European bisons is replaced by tryptophan in the long-lived animals. This study is the first to determine longevity-associated variants in genes in European bison. Association of the FER1L6 gene with longevity shows a possible sex dependency.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10613 - Zoology

Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2022
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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