Identification of genes associated with longevity in dogs: 9 candidate genes described in Cavalier King Charles Spaniel
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378050%3A_____%2F25%3A00617708" target="_blank" >RIV/68378050:_____/25:00617708 - isvavai.cz</a>
Result on the web
<a href="https://doi.org/10.1016/j.vas.2024.100420" target="_blank" >https://doi.org/10.1016/j.vas.2024.100420</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.vas.2024.100420" target="_blank" >10.1016/j.vas.2024.100420</a>
Alternative languages
Result language
angličtina
Original language name
Identification of genes associated with longevity in dogs: 9 candidate genes described in Cavalier King Charles Spaniel
Original language description
In the past years, dogs have served as a convenient natural model organism for longevity due to their similarity with humans concerning not only their environment but also the diseases and complications occurring in older age. Since many dog breeds have significantly shorter lifespan than their closely related breeds, identification of genes associated with longevity may help to elucidate its background and serve as a possible tool for selective breeding of long-living dogs. This genome-wide association study (GWAS) was undertaken to identify the candidate genes associated with longevity in Cavalier King Charles Spaniel individuals that have reached the age of more than 13 years. We described 15 SNPs localized in nine genes: B3GALNT1, NLRP1 like, PARP14, IQCJSCHIP1, COL9A1, COL19A1, SDHAF4, B3GAT2, and DIRC2 that are associated with longevity in purebred Cavalier King Charles Spaniels. These results are promising for future research and possible selective breeding of companion dogs with extended lifespan.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10608 - Biochemistry and molecular biology
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2025
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Veterinary and Animal Sciences
ISSN
2451-943X
e-ISSN
2451-943X
Volume of the periodical
27
Issue of the periodical within the volume
March
Country of publishing house
NL - THE KINGDOM OF THE NETHERLANDS
Number of pages
9
Pages from-to
100420
UT code for WoS article
001392101100001
EID of the result in the Scopus database
2-s2.0-85212431339