Microbe-mediated intestinal NOD2 stimulation improves linear growth of undernourished infant mice
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378050%3A_____%2F23%3A00573086" target="_blank" >RIV/68378050:_____/23:00573086 - isvavai.cz</a>
Alternative codes found
RIV/61388971:_____/23:00573086
Result on the web
<a href="https://www.science.org/doi/10.1126/science.ade9767" target="_blank" >https://www.science.org/doi/10.1126/science.ade9767</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1126/science.ade9767" target="_blank" >10.1126/science.ade9767</a>
Alternative languages
Result language
angličtina
Original language name
Microbe-mediated intestinal NOD2 stimulation improves linear growth of undernourished infant mice
Original language description
The intestinal microbiota is known to influence postnatal growth. We previously found that a strain of Lactiplantibacillus plantarum (strain LpWJL) buffers the adverse effects of chronic undernutrition on the growth of juvenile germ-free mice. Here, we report that LpWJLsustains the postnatal growth of malnourished conventional animals and supports both insulin-like growth factor-1 (IGF-1) and insulin production and activity. We have identified cell walls isolated from LpWJL, as well as muramyl dipeptide and mifamurtide, as sufficient cues to stimulate animal growth despite undernutrition. Further, we found that NOD2 is necessary in intestinal epithelial cells for LpWJL-mediated IGF-1 production and for postnatal growth promotion in malnourished conventional animals. These findings indicate that, coupled with renutrition, bacteria cell walls or purified NOD2 ligands have the potential to alleviate stunting.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
30102 - Immunology
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2023
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Science
ISSN
0036-8075
e-ISSN
1095-9203
Volume of the periodical
379
Issue of the periodical within the volume
6634 SI
Country of publishing house
US - UNITED STATES
Number of pages
8
Pages from-to
826-833
UT code for WoS article
000981616600014
EID of the result in the Scopus database
2-s2.0-85148680225