The role of the gut microbiota and Lactiplantibacillus plantarum wjl strain in Juvenile growth during chronic undernutritionn

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388971%3A_____%2F23%3A00580480" target="_blank" >RIV/61388971:_____/23:00580480 - isvavai.cz</a>

Result on the web

<a href="https://www.old-herborn-university.de/wp-content/uploads/publications/books/OHUni_book_35_article_2.pdf" target="_blank" >https://www.old-herborn-university.de/wp-content/uploads/publications/books/OHUni_book_35_article_2.pdf</a>

DOI - Digital Object Identifier

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Result language

angličtina

Original language name

The role of the gut microbiota and Lactiplantibacillus plantarum wjl strain in Juvenile growth during chronic undernutritionn

Original language description

The World Health Organization defines malnutrition as a deficiency, excess, or imbalance in a person's energy and/or nutrient intake. However, it is becoming increasingly clear that not only diet per se, but also the intestinal microbiota plays a fundamental role in the development of diseases associated with malnutrition. Next-generation sequencing, the renewed interest in bac- terial culturing techniques, and the use of gnotobiotic models have enabled major advances in causally linking the role of the microbiota and specificnbacterial strains in the aetiology/prevention of diseases associated with undernutrition, including wasting, stunting, and underweight. We have shown that the Lactiplantibacillus plantarum strain, selected in the gnotobiotic invertebrate Drosophila model for its growth-promoting properties, is able to increase the growth of juvenile undernourished mice in both gnotobiotic and specific pathogen-free animals, and that this effect is dependent on the expression of the NOD2 receptor by intestinal epithelial cells. These results suggest that administration of selected bacterial strains may represent a novel strategy for alleviating the persistent stunting that is one of the long-term consequences of undernutrition, which still affects millions of children under five years of age in low- and middle-income countries.

Czech name

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Czech description

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Type

O - Miscellaneous

CEP classification

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OECD FORD branch

30102 - Immunology

Project

<a href="/en/project/GM21-19640M" target="_blank" >GM21-19640M: Specific bacterial strains and bacteria-derived postbiotics for amelioration of long-term sequelae of malnutrition</a><br>

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2023

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů