Highly variable biological effects of statins on cancer, non-cancer, and stem cells in vitro

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378050%3A_____%2F24%3A00586779" target="_blank" >RIV/68378050:_____/24:00586779 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11110/24:10481931 RIV/60461373:22310/24:43930346 RIV/60461373:22330/24:43930346 RIV/00064165:_____/24:10481931

Result on the web

<a href="https://www.nature.com/articles/s41598-024-62615-w" target="_blank" >https://www.nature.com/articles/s41598-024-62615-w</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1038/s41598-024-62615-w" target="_blank" >10.1038/s41598-024-62615-w</a>

Result language

angličtina

Original language name

Highly variable biological effects of statins on cancer, non-cancer, and stem cells in vitro

Original language description

Statins, the drugs used for the treatment of hypercholesterolemia, have come into the spotlight not only as chemoadjuvants, but also as potential stem cell modulators in the context of regenerative therapy. In our study, we compared the in vitro effects of all clinically used statins on the viability of human pancreatic cancer (MiaPaCa-2) cells, non-cancerous human embryonic kidney (HEK 293) cells and adipose-derived mesenchymal stem cells (ADMSC). Additionally, the effect of statins on viability of MiaPaCa-2 and ADMSC cells spheroids was tested. Furthermore, we performed a microarray analysis on ADMSCs treated with individual statins (12 mu M) and compared the importance of the effects of statins on gene expression between stem cells and pancreatic cancer cells. Concentrations of statins that significantly affected cancer cells viability (< 40 mu M) did not affect stem cells viability after 24 h. Moreover, statins that didn't affect viability of cancer cells grown in a monolayer, induce the disintegration of cancer cell spheroids. The effect of statins on gene expression was significantly less pronounced in stem cells compared to pancreatic cancer cells. In conclusion, the low efficacy of statins on non-tumor and stem cells at concentrations sufficient for cancer cells growth inhibition, support their applicability in chemoadjuvant tumor therapy.

Czech name

—

Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

10601 - Cell biology

Project

<a href="/en/project/EF16_019%2F0000785" target="_blank" >EF16_019/0000785: Center for Tumor Ecology - Research of the cancer microenvironment supporting cancer growth and spread</a><br>

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2024

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Scientific Reports

ISSN

2045-2322

e-ISSN

2045-2322

Volume of the periodical

14

Issue of the periodical within the volume

1

Country of publishing house

US - UNITED STATES

Number of pages

11

Pages from-to

11830

UT code for WoS article

001230489600005

EID of the result in the Scopus database

2-s2.0-85194126241