Design and synthesis of a novel trinuclear palladium(II) complex containing an oxime chelate ligand: determining the interaction mechanism with the DNA groove and BSA site I by spectroscopic and molecular dynamics simulation approaches

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378271%3A_____%2F15%3A00456346" target="_blank" >RIV/68378271:_____/15:00456346 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1039/C5NJ01280E" target="_blank" >http://dx.doi.org/10.1039/C5NJ01280E</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1039/C5NJ01280E" target="_blank" >10.1039/C5NJ01280E</a>

Result language
angličtina
Original language name
Design and synthesis of a novel trinuclear palladium(II) complex containing an oxime chelate ligand: determining the interaction mechanism with the DNA groove and BSA site I by spectroscopic and molecular dynamics simulation approaches
Original language description
The novel trinuclear Pd(II) complex with an aryl oxime ligand, [Pd3(C,N-(C6H4C(Cl)QNO)-4)6], was synthesized and structurally characterized by elemental analysis (C, H, N), IR, resonance signals in the NMR, and single crystal X-ray crystallography. The interaction ability of the complex with native calf thymus DNA (CT-DNA) was monitored as a function of the metal complex?DNA molar ratio by UV-Vis absorption spectrophotometry, fluorescence spectroscopy, circular dichroism (CD) and thermal denaturation methods. All the experimental evidence indicated that this complex could strongly bind to CT-DN A via a groove mechanism. Further, the albumin interactions of the complex were investigated using fluorescence quenching and synchronous fluorescence spectra.The results of fluorescence titration suggested that the fluorescence quenching of BSA by the complex was a static quenching procedure.
Czech name
—
Czech description
—

Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CC - Organic chemistry
OECD FORD branch
—

Project
<a href="/en/project/GA14-03276S" target="_blank" >GA14-03276S: Aspherical effects and their application for statistically correct crystal structure analysis</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Similar results(10)