Lysosomal nanotoxicity: Impact of nanomedicines on lysosomal function

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378271%3A_____%2F23%3A00571307" target="_blank" >RIV/68378271:_____/23:00571307 - isvavai.cz</a>
Alternative codes found
RIV/00023001:_____/23:00083943
Result on the web
<a href="http://doi.org/10.1016/j.addr.2023.114828" target="_blank" >http://doi.org/10.1016/j.addr.2023.114828</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.addr.2023.114828" target="_blank" >10.1016/j.addr.2023.114828</a>

Result language
angličtina
Original language name
Lysosomal nanotoxicity: Impact of nanomedicines on lysosomal function
Original language description
Although several nanomedicines got clinical approval over the past two decades, the clinical translation rate is relatively small so far. There are many post-surveillance withdrawals of nanomedicines caused by various safety issues. For successful clinical advancement of nanotechnology, it is of unmet need to realize cellular and molecular foundation of nanotoxicity. Current data suggest that lysosomal dysfunction caused by nanoparticles is emerging as the most common intracellular trigger of nanotoxicity. This review analyzes prospect mechanisms of lysosomal dysfunction-mediated toxicity induced by nanoparticles. We summarized and critically assessed adverse drug reactions of current clinically approved nanomedicines.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
10610 - Biophysics

Project
<a href="/en/project/EF16_019%2F0000760" target="_blank" >EF16_019/0000760: Solid State Physics for 21st century</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2023
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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