Modulation of calcium signaling and metabolic pathways in endothelial cells with magnetic fields
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378271%3A_____%2F24%3A00584436" target="_blank" >RIV/68378271:_____/24:00584436 - isvavai.cz</a>
Result on the web
<a href="https://hdl.handle.net/11104/0356498" target="_blank" >https://hdl.handle.net/11104/0356498</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1039/d3na01065a" target="_blank" >10.1039/d3na01065a</a>
Alternative languages
Result language
angličtina
Original language name
Modulation of calcium signaling and metabolic pathways in endothelial cells with magnetic fields
Original language description
Calcium signaling plays a crucial role in various physiological processes, including muscle contraction, cell division, and neurotransmitter release. Dysregulation of calcium levels and signaling has been linked to a range of pathological conditions such as neurodegenerative disorders, cardiovascular disease, and cancer. Here, we propose a theoretical model that predicts the modulation of calcium ion channel activity and calcium signaling in the endothelium through the application of either a time-varying or static gradient magnetic field (MF). This modulation is achieved by exerting magnetic forces or torques on either biogenic or non-biogenic magnetic nanoparticles that are bound to endothelial cell membranes. Since calcium signaling in endothelial cells induces neuromodulation and influences blood flow control, treatment with a magnetic field shows promise for regulating neurovascular coupling and treating vascular dysfunctions associated with aging and neurodegenerative disorders. Furthermore, magnetic treatment can enable control over the decoding of Ca signals, ultimately impacting protein synthesis. The ability to modulate calcium wave frequencies using MFs and the MF-controlled decoding of Ca signaling present promising avenues for treating diseases characterized by calcium dysregulation.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10610 - Biophysics
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2024
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Nanoscale Advances
ISSN
2516-0230
e-ISSN
2516-0230
Volume of the periodical
6
Issue of the periodical within the volume
4
Country of publishing house
GB - UNITED KINGDOM
Number of pages
20
Pages from-to
1163-1182
UT code for WoS article
001151620700001
EID of the result in the Scopus database
2-s2.0-85184026738