DOTA DECORATED HYDROXYAPATITE NANOPARTICLES LABELLED WITH 68Ga

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68407700%3A21340%2F18%3A00323742" target="_blank" >RIV/68407700:21340/18:00323742 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
DOTA DECORATED HYDROXYAPATITE NANOPARTICLES LABELLED WITH 68Ga
Original language description
Hydroxyapatite nanoparticles (HAp-NPs) are widely used in medicine because of their biocompatibility and stability in various media [1]. The HAp-NPs also belong to promising drug carrier systems for medicinal radionuclides such as Ga-68 as the part of multipurpose theranostic system. Diagnosis and therapy of some diseases is expected to be very accurate and beneficial. Labelling was carried out with pristine NPs and NPs decorated with selected ligands: DOTA, NOTA, TETA and TRAP (0.05 mg). Best result was obtained in a procedure when the 68Ga was added to the NPs dispersion in the DOTA ligand. Further experiments have shown that uptake kinetics is quite fast (over 90% yield within 5 minutes) and good stability of 68Ga-DOTA-HAp-NPs nanoconstruct in a physiological saline (more than 95 % of activity remained bound to the NPs in 4 hours).
Czech name
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Czech description
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Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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