COMPLEXES OF STIGMASTEROL HEMIESTERS WITH L, D-TRYPTOPHAN

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68407700%3A21340%2F18%3A00323791" target="_blank" >RIV/68407700:21340/18:00323791 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
COMPLEXES OF STIGMASTEROL HEMIESTERS WITH L, D-TRYPTOPHAN
Original language description
Various biological activities of steroid compounds have been well known for decades now. Specific receptor binding assures selective distribution of radiolabelled steroid in the body. In this work we present synthesis of four conjugates of stigmasterol hemiesters with L,D-tryptophan and their complexes with platinum (II). Furthermore, we introduce preliminary results of labelling one of DOTA modified ligands with 68Ga. Debenzylation of prepared conjugates resulted in desired products (I - IV) in 74-88% yields. Platinum (II) complexes of obtained conjugates I - IV were prepared by a reaction of steroidal ligand with potassium tetrachloroplatinate in DMF. Steroidal ligand was modified by its reaction with a DOTA derivative in the presence of T3P. Labelling of obtained ligand with 68Ga was performed using eluate from 68Ge/68Ga generator in citrate buffer during 30 min at 80°C. Yield of radiolabelling (about 50%) was determined by HPLC.
Czech name
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Czech description
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Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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