Simulation of Adenosine Receptor A2b Subtype and Molecules of Activators and Inhibitors Interaction in Silico
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68407700%3A21460%2F11%3A00184841" target="_blank" >RIV/68407700:21460/11:00184841 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Simulation of Adenosine Receptor A2b Subtype and Molecules of Activators and Inhibitors Interaction in Silico
Original language description
The research's aim was to create computer models of A2B subtype of adenosine receptor, and also its activators and inhibitors; using these models to analyze special features of interaction between A2B subtype of adenosine receptor molecule and moleculesof different activators and inhibitors in silico. The modeling of ligand-receptor interaction was made on the supercomputer SKIF Cyberia using AutoDock 4.0 as the part of MGL Tools 1.4.5. In this research work, realized on the unique A2B adenosine receptor computer model, it was shown, that both activators and inhibitors produce the hydrogen bindings with different amino acids as a result of interaction between them and A2B adenosine receptor. The current investigation detected the amino acids, playingthe main part in activation A2B subtype of adenosine receptor. To make final decision about the role of aforesaid acids in receptor activation it is needed to implement the test with A2B subtype of adenosine receptor in vitro.
Czech name
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Czech description
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Classification
Type
D - Article in proceedings
CEP classification
IN - Informatics
OECD FORD branch
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Result continuities
Project
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Continuities
V - Vyzkumna aktivita podporovana z jinych verejnych zdroju
Others
Publication year
2011
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Article name in the collection
Proceedings of the Young Biomedical Engineers and Researchers Conference
ISBN
978-80-553-0596-7
ISSN
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e-ISSN
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Number of pages
4
Pages from-to
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Publisher name
Technical University of Košice
Place of publication
Košice
Event location
Košice
Event date
Jul 1, 2010
Type of event by nationality
WRD - Celosvětová akce
UT code for WoS article
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