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Simulation of Adenosine Receptor A2b Subtype and Molecules of Activators and Inhibitors Interaction in Silico

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68407700%3A21460%2F11%3A00184841" target="_blank" >RIV/68407700:21460/11:00184841 - isvavai.cz</a>

  • Result on the web

  • DOI - Digital Object Identifier

Alternative languages

  • Result language

    angličtina

  • Original language name

    Simulation of Adenosine Receptor A2b Subtype and Molecules of Activators and Inhibitors Interaction in Silico

  • Original language description

    The research's aim was to create computer models of A2B subtype of adenosine receptor, and also its activators and inhibitors; using these models to analyze special features of interaction between A2B subtype of adenosine receptor molecule and moleculesof different activators and inhibitors in silico. The modeling of ligand-receptor interaction was made on the supercomputer SKIF Cyberia using AutoDock 4.0 as the part of MGL Tools 1.4.5. In this research work, realized on the unique A2B adenosine receptor computer model, it was shown, that both activators and inhibitors produce the hydrogen bindings with different amino acids as a result of interaction between them and A2B adenosine receptor. The current investigation detected the amino acids, playingthe main part in activation A2B subtype of adenosine receptor. To make final decision about the role of aforesaid acids in receptor activation it is needed to implement the test with A2B subtype of adenosine receptor in vitro.

  • Czech name

  • Czech description

Classification

  • Type

    D - Article in proceedings

  • CEP classification

    IN - Informatics

  • OECD FORD branch

Result continuities

  • Project

  • Continuities

    V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Others

  • Publication year

    2011

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Article name in the collection

    Proceedings of the Young Biomedical Engineers and Researchers Conference

  • ISBN

    978-80-553-0596-7

  • ISSN

  • e-ISSN

  • Number of pages

    4

  • Pages from-to

  • Publisher name

    Technical University of Košice

  • Place of publication

    Košice

  • Event location

    Košice

  • Event date

    Jul 1, 2010

  • Type of event by nationality

    WRD - Celosvětová akce

  • UT code for WoS article