ADENOSINE A2B RECEPTOR INTERACTION INVESTIGATION IN SILICO

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F70883521%3A28140%2F10%3A63509207" target="_blank" >RIV/70883521:28140/10:63509207 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

ADENOSINE A2B RECEPTOR INTERACTION INVESTIGATION IN SILICO

Original language description

This research was devoted to study of adenosine receptors A2B subtype, which is not full studied. The research?s aim was to create computer models of A2B adenosine receptor, and also its 9 activators and 15inhibitors; using these models to analyze special features of interaction between A2B adenosine receptor molecule and molecules of different activators and inhibitors in silico. The amino acid sequence of A2B receptors was taken from open source in the NCBI data base, ID: NP_000667.1, for modeling ?2Badenosine receptor and its mutant forms the MODELLER software was used. The modeling of ligand- receptor interaction was made on the supercomputer SKIF Cyberia (Tomsk State University, Russia) using AutoDock 4.0 as the part of MGL Tools 1.4.5. In this research work, realized on the unique A2B adenosine receptor computer model, it was shown, that both activators and inhibitors produce the hydrogen bindings with different amino acids as a result of interaction between them and A2B adenosi

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

JD - Use of computers, robotics and its application

OECD FORD branch

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Project

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Continuities

S - Specificky vyzkum na vysokych skolach

Publication year

2010

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Physiological research

ISSN

1802-9973

e-ISSN

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Volume of the periodical

59

Issue of the periodical within the volume

5

Country of publishing house

CZ - CZECH REPUBLIC

Number of pages

38

Pages from-to

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UT code for WoS article

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EID of the result in the Scopus database

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