What does the Tpeak-Tend interval reflect? An experimental and model study

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68407700%3A21460%2F13%3A00212492" target="_blank" >RIV/68407700:21460/13:00212492 - isvavai.cz</a>
Result on the web
<a href="http://www.ncbi.nlm.nih.gov/pubmed/23473669" target="_blank" >http://www.ncbi.nlm.nih.gov/pubmed/23473669</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.jelectrocard.2013.02.001" target="_blank" >10.1016/j.jelectrocard.2013.02.001</a>

Result language
angličtina
Original language name
What does the Tpeak-Tend interval reflect? An experimental and model study
Original language description
Background It is unclear whether the Tpeak-Tend interval is an index of the transmural or the total dispersion of repolarization. Methods We examined the Tpeak-Tend interval using a computer model of the rabbit heart ventricles based on experimentally measured transmural, apicobasal, and interventricular gradients of action potential duration. Results Experimentally measured activation-recovery intervals increased from apex to base, from the left ventricle to the right ventricle, and in the apical portion of the left ventricle from epicardium to endocardium and from the right side of septum to the left side. The simulated Tpeak corresponded to the earliest end of repolarization, whereas the Tend corresponded to the latest end of repolarization. The different components of the global repolarization dispersion were discerned by simulation. Conclusions The Tpeak-T end interval corresponds to the global dispersion of repolarization with distinct contributions of the apicobasal and transmur
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
ED - Physiology
OECD FORD branch
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Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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