Models of a PaO2 Course during a Stepwise Change of Continuous Distending Pressure in HFOV

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68407700%3A21460%2F16%3A00242992" target="_blank" >RIV/68407700:21460/16:00242992 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.1109/MCSI.2015.43" target="_blank" >http://dx.doi.org/10.1109/MCSI.2015.43</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1109/MCSI.2015.43" target="_blank" >10.1109/MCSI.2015.43</a>

Result language

angličtina

Original language name

Models of a PaO2 Course during a Stepwise Change of Continuous Distending Pressure in HFOV

Original language description

Acute respiratory distress syndrome (ARDS) is an acute severe lung disease commonly encountered in intensive care units. High-frequency oscillatory ventilation (HFOV) could offer effective lung protective ventilation by delivering very low tidal volumes around constant relatively higher continuous distending pressure (CDP) at frequencies of 3 to 15 Hz. Optimization of CDP is not an easy task and it is titrated empirically in the clinical practice. The aim of this study is to investigate if the level of CDP affects the shape of the partial pressure of oxygen (PaO2) response of the organism to the CDP stepwise changes. Ten pigs were used in this study. In order to mimic ARDS, surfactant deficiency was induced by a double or triple lung lavage. Every 10 minutes, CDP was stepwise increased by 2 cmH2O. Increase in CDP was stopped when severe signs of hemodynamics deterioration were observed and then, CDP was stepwise decreased by 2 cmH2O to its initial value. For each CDP step performed, we fitted PaO2 with a one-term power model as follows: y=a.x b, where x is the time, a is the amplitude of the model and exponent b reflects the shape of the model. For values of PaO2 200mmHg, PaO2 course follows a shape modelled exclusively by a root function. It is not possible to describe a relationship between the shape of the PaO2 course and the values of CDP. When alveoli are not recruited at all, oxygenation is more sensitive to changes in lung volume and aeration and thus, PaO2 grows or drops rapidly following linear and/or quadratic functions. Instead of, when alveoli are open and recruited changes in PaO2 are less sensitive to minor changes in lung aeration and thus, PaO2 grows and drops slower following only root function. The CDP level does not affect the response of organism in terms of shape change of PaO2, probably due to the fact that the recruitment occurs at different values in each pig.

Czech name

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Czech description

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Type

D - Article in proceedings

CEP classification

FS - Medical facilities, apparatus and equipment

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2016

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Article name in the collection

2015 2nd International Conference on Mathematics and Computers in Sciences and in Industry, MCSI 2015

ISBN

978-1-4799-8673-6

ISSN

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e-ISSN

—

Number of pages

6

Pages from-to

66-71

Publisher name

Institute of Electrical and Electronics Engineers

Place of publication

Piscataway

Event location

Sliema; Malta

Event date

Aug 17, 2015

Type of event by nationality

WRD - Celosvětová akce

UT code for WoS article

000380543500011