Models of PaO2 response to the continuous distending pressure maneuver during high frequency oscillatory ventilation in healthy and ARDS lung model pigs

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68407700%3A21460%2F16%3A00242580" target="_blank" >RIV/68407700:21460/16:00242580 - isvavai.cz</a>

Result on the web

<a href="http://www.tandfonline.com/eprint/cn7bnqbtvaE9p5yUwS5t/full" target="_blank" >http://www.tandfonline.com/eprint/cn7bnqbtvaE9p5yUwS5t/full</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3109/01902148.2016.1145307" target="_blank" >10.3109/01902148.2016.1145307</a>

Result language

angličtina

Original language name

Models of PaO2 response to the continuous distending pressure maneuver during high frequency oscillatory ventilation in healthy and ARDS lung model pigs

Original language description

Purpose/Aim: High-frequency oscillatory ventilation (HFOV) is a method of ventilation that theoretically achieves the goals of lung protective ventilation in acute respiratory distress syndrome (ARDS) patients. It is characterized by a rapid delivery of small tidal volumes at high frequencies oscillating around a continuous distending pressure (CDP). Optimization of CDP is not an easy task and it is titrated empirically in the clinical practice. The aim of this study is to investigate whether the level of CDP consistently affects the shape of the partial pressure of oxygen (PaO2) response to stepwise changes in CDP during HFOV of healthy and ARDS-induced pigs. Materials and Methods: We performed two stepwisemaneuvers of CDP in 14 pigs: one before and one after the lung lavage, inducing ARDS. For each CDP step performed,we fitted a segment of PaO2 curvewith a one-term power model. Results: PaO2 course follows shapes modeled by root, linear, quadratic, and cubic functions for values of PaO2 110 mmHg and PaO2 200 mmHg, before and after the lung lavage, respectively. PaO2 course follows a shape modeled exclusively by a root function for values of PaO2 > 110 mmHg and PaO2 > 200 mmHg, before and after the lung lavage, respectively. It is not possible to describe a relationship between the shape of the PaO2 course and the values of CDP. Conclusions: The PaO2 curve may give information about the level of recruitment of alveoli, but cannot be used for optimization of CDP level during HFOV in healthy and ARDS lung model pigs.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FC - Pneumology

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2016

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Experimental Lung Research

ISSN

0190-2148

e-ISSN

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Volume of the periodical

42

Issue of the periodical within the volume

2

Country of publishing house

GB - UNITED KINGDOM

Number of pages

8

Pages from-to

87-94

UT code for WoS article

000373973600004

EID of the result in the Scopus database

2-s2.0-84963764000