The potential of constrained SAR focusing for hyperthermia treatment planning: analysis for the head & neck region
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68407700%3A21460%2F19%3A00326454" target="_blank" >RIV/68407700:21460/19:00326454 - isvavai.cz</a>
Result on the web
<a href="https://doi.org/10.1088/1361-6560/aaf0c4" target="_blank" >https://doi.org/10.1088/1361-6560/aaf0c4</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1088/1361-6560/aaf0c4" target="_blank" >10.1088/1361-6560/aaf0c4</a>
Alternative languages
Result language
angličtina
Original language name
The potential of constrained SAR focusing for hyperthermia treatment planning: analysis for the head & neck region
Original language description
Clinical trials have shown that hyperthermia is a potent adjuvant to conventional cancer treatments, but the temperatures currently achieved in the clinic are still suboptimal. Hyperthermia treatment planning simulations have potential to improve the heating profile of phased-array applicators. An important open challenge is the development of an effective optimization procedure that enables uniform heating of the target region while keeping temperature below a threshold in healthy tissues. In this work, we analyzed the effectiveness and efficiency of a recently proposed optimization approach, i.e. focusing via constrained power optimization (FOCO), using 3D simulations of twelve clinical patient specific models. FOCO performance was compared against a clinically used particle swarm based optimization approach. Evaluation metrics were target coverage at the 25% iso-SAR level, target hotspot quotient, median target temperature (T50) and computational requirements. Our results show that, on average, constrained power focusing performs slightly better than the clinical benchmark (T50 °C), but outperforms this clinical benchmark for large target volumes (40 cm, T50 °C). In addition, the results are achieved in a shorter time (%) and are repeatable because the approach is formulated as a convex optimization problem.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
20201 - Electrical and electronic engineering
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Physics in Medicine and Biology
ISSN
0031-9155
e-ISSN
1361-6560
Volume of the periodical
64
Issue of the periodical within the volume
1
Country of publishing house
GB - UNITED KINGDOM
Number of pages
10
Pages from-to
1-10
UT code for WoS article
000454239200006
EID of the result in the Scopus database
2-s2.0-85058918246