Composite 3D Printed Scaffold with Structured Electrospun Nanofibers Promotes Chondrocyte Adhesion and Infiltration

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68407700%3A21720%2F18%3A00317966" target="_blank" >RIV/68407700:21720/18:00317966 - isvavai.cz</a>
Alternative codes found
RIV/68378041:_____/18:00482687 RIV/46747885:24410/18:00006035 RIV/46747885:24620/18:00006035
Result on the web
<a href="http://dx.doi.org/10.1080/19336918.2017.1385713" target="_blank" >http://dx.doi.org/10.1080/19336918.2017.1385713</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1080/19336918.2017.1385713" target="_blank" >10.1080/19336918.2017.1385713</a>

Result language
angličtina
Original language name
Composite 3D Printed Scaffold with Structured Electrospun Nanofibers Promotes Chondrocyte Adhesion and Infiltration
Original language description
Additive manufacturing, also called 3D printing, is an effective method for preparing scaffolds with defined structure and porosity. The disadvantage of the technique is the excessive smoothness of the printed fibers, which does not support cell adhesion. In the present study, a 3D printed scaffold was combined with electrospun classic or structured nanofibers to promote cell adhesion. Structured nanofibers were used to improve the infiltration of cells into the scaffold. Electrospun layers were connected to 3D printed fibers by gluing, thus enabling the fabrication of scaffolds with unlimited thickness. The composite 3D printed/nanofibrous scaffolds were seeded with primary chondrocytes and tested in vitro for cell adhesion, proliferation and differentiation. The experiment showed excellent cell infiltration, viability, and good cell proliferation. On the other hand, partial chondrocyte dedifferentiation was shown. Other materials supporting chondrogenic differentiation will be investigated in future studies.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
20505 - Composites (including laminates, reinforced plastics, cermets, combined natural and synthetic fibre fabrics; filled composites)

Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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