Study of chemical modification of hyaluronic acid

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F70883521%3A28110%2F01%3A63500362" target="_blank" >RIV/70883521:28110/01:63500362 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Study of chemical modification of hyaluronic acid
Original language description
The most important mucopolysaccharide, hyaluronic acid (HA), is a linear carbohydrate polymer. Its disaccharide monomeric unit is built up of N-acetyl D-glucosamine and D-glucuronic acid interconnected via b (1#4) and b (1#4) interglycosidic bonds. In aqueous solutions HA forms rigid domains built up from about 10 - 20 monomer units strongly bound by the systém of intra- and inter- molecular hydrogen bonds, thus producing its characteristics of secondary a tertiary configurations. These structures couldbe strongly influenced by insertion on n-alkyl spacers as a branch into this systems. For this reason, five n-alkyl derivatives on the CH2-OH groups of hyaluronic acid, from n-C6- to n-C16- were prepared. The following properties of these products are reviewed: Kinetic parameters of dissolution, study of enzymatic degradation, thermal analysis and measurements of its electric properties.
Czech name
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Czech description
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Publication year
2001
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Article name in the collection
Structure and Stability of Biomacromolecules SSB'01
ISBN
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ISSN
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e-ISSN
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Number of pages
2
Pages from-to
89-90
Publisher name
Slovak Academy of Sciences, P. J. Šafárik University
Place of publication
Košice
Event location
Košice, Slovenská Republika
Event date
Sep 12, 2001
Type of event by nationality
WRD - Celosvětová akce
UT code for WoS article
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