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N-acetylglucoseamine as a signalling molecule triggering hyaluronic acid increase in streptococcus zooepidemicus

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26310%2F16%3APU120651" target="_blank" >RIV/00216305:26310/16:PU120651 - isvavai.cz</a>

  • Result on the web

    <a href="http://dx.doi.org/10.1016/j.nbt.2016.06.1248" target="_blank" >http://dx.doi.org/10.1016/j.nbt.2016.06.1248</a>

  • DOI - Digital Object Identifier

Alternative languages

  • Result language

    angličtina

  • Original language name

    N-acetylglucoseamine as a signalling molecule triggering hyaluronic acid increase in streptococcus zooepidemicus

  • Original language description

    Hyaluronic acid is a linear polysaccharide composed of alternating D-glucuronic acid and N-acetylglucoseamine (GlcNAc) linked by beta(1, 4) and beta(1, 3) glycosidi bonds. Industrially, HA has been manufactured by fermentation of group C streptococci since the 1980s. HA is produced by processive synthase from the activated precursors UDP-glucuronic acid and UDP-N-Acetylglucoseamin. It was found that external supplementation by GlcNAc can increase HA production and its molecular weight. The aim of this study was to evaluate whether external GlcNAc acts as a direct substrate for hyaluronic acid biosynthesis or it works by different mechanism.

  • Czech name

  • Czech description

Classification

  • Type

    O - Miscellaneous

  • CEP classification

  • OECD FORD branch

    10609 - Biochemical research methods

Result continuities

  • Project

  • Continuities

    S - Specificky vyzkum na vysokych skolach

Others

  • Publication year

    2016

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů