N-acetylglucoseamine as a signalling molecule triggering hyaluronic acid increase in streptococcus zooepidemicus
Result description
Hyaluronic acid is a linear polysaccharide composed of alternating D-glucuronic acid and N-acetylglucoseamine (GlcNAc) linked by beta(1, 4) and beta(1, 3) glycosidi bonds. Industrially, HA has been manufactured by fermentation of group C streptococci since the 1980s. HA is produced by processive synthase from the activated precursors UDP-glucuronic acid and UDP-N-Acetylglucoseamin. It was found that external supplementation by GlcNAc can increase HA production and its molecular weight. The aim of this study was to evaluate whether external GlcNAc acts as a direct substrate for hyaluronic acid biosynthesis or it works by different mechanism.
Keywords
The result's identifiers
Result code in IS VaVaI
Result on the web
DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
N-acetylglucoseamine as a signalling molecule triggering hyaluronic acid increase in streptococcus zooepidemicus
Original language description
Hyaluronic acid is a linear polysaccharide composed of alternating D-glucuronic acid and N-acetylglucoseamine (GlcNAc) linked by beta(1, 4) and beta(1, 3) glycosidi bonds. Industrially, HA has been manufactured by fermentation of group C streptococci since the 1980s. HA is produced by processive synthase from the activated precursors UDP-glucuronic acid and UDP-N-Acetylglucoseamin. It was found that external supplementation by GlcNAc can increase HA production and its molecular weight. The aim of this study was to evaluate whether external GlcNAc acts as a direct substrate for hyaluronic acid biosynthesis or it works by different mechanism.
Czech name
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Czech description
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Classification
Type
O - Miscellaneous
CEP classification
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OECD FORD branch
10609 - Biochemical research methods
Result continuities
Project
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Continuities
S - Specificky vyzkum na vysokych skolach
Others
Publication year
2016
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Result type
O - Miscellaneous
OECD FORD
Biochemical research methods
Year of implementation
2016