Influence of self-organized fluid flows on structure and network formation in self-supporting layers made of hyaluronan

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F70883521%3A28110%2F23%3A63571140" target="_blank" >RIV/70883521:28110/23:63571140 - isvavai.cz</a>
Alternative codes found
RIV/70883521:28610/23:63571140
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Influence of self-organized fluid flows on structure and network formation in self-supporting layers made of hyaluronan
Original language description
The spatial arrangement of bio-macromolecular systems affects their function and physiological role. This study presents a new approach to induce changes in the secondary and tertiary structure of macromolecules without altering pH or ionic strength. By utilizing self-organized fluid flows, known as Bénard-Marangoni convective instability, we observed alterations in mean coil size, thermal stability, and self-organizing capabilities of hyaluronic acid. These changes manifested through modified surface activity and the formation of self-supporting polymeric film. Additionally, we investigated the factors influencing network formation and aggregation of hyaluronan on mica surfaces. Temperature-induced self-organization in fluid state as well as molecular weight or concentration influenced the macromolecular arrangement such as aggregate size or fibrillar network density at the liquid-solid interface. The understanding of hyaluronan's conformational variability is of great importance as it governs its processability, and formulations in coatings and self-supporting layers with improved mechanical properties.
Czech name
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Czech description
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Project
<a href="/en/project/GA22-33307S" target="_blank" >GA22-33307S: Development of novel 3D hierarchically structured polysaccharides and proteins porous systems</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2023
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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