Fabrication of textured silk films via phase-separation approach for applica-tions in regenerative medicine

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F70883521%3A28110%2F23%3A63571159" target="_blank" >RIV/70883521:28110/23:63571159 - isvavai.cz</a>
Alternative codes found
RIV/70883521:28610/23:63571159
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Fabrication of textured silk films via phase-separation approach for applica-tions in regenerative medicine
Original language description
The poor cell adhesion properties of silk protein (Bombyx mori) surfaces require additional surface treatments to increase the adhesive capabilities of selected cell lines. In this research, coatings made of the silk protein were structured using a dosed addition of solvent/non-solvent mixtures. To control over the surface modification process, we developed a specialized device that allows precise setting of process parameters, such as time delays or dosing volumes of droplets. By optimizing the process parameters for surface modification, we successfully controlled the formation of nano- to microporous structures on the silk surfaces. The surface modification also significantly depended on the initial secondary conformations of the protein i.e. content of beta-sheet structures. The textured surfaces exhibited improved properties for adhesion and proliferation of diverse cell lines, thus greatly expanding the potential applications of silk-based materials in the field of regenerative medicine.
Czech name
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Czech description
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Project
<a href="/en/project/GA22-33307S" target="_blank" >GA22-33307S: Development of novel 3D hierarchically structured polysaccharides and proteins porous systems</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2023
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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