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Structuring of silk-fibroin surfaces by phase separation

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F70883521%3A28610%2F22%3A63557720" target="_blank" >RIV/70883521:28610/22:63557720 - isvavai.cz</a>

  • Alternative codes found

    RIV/70883521:28110/22:63557720

  • Result on the web

  • DOI - Digital Object Identifier

Alternative languages

  • Result language

    angličtina

  • Original language name

    Structuring of silk-fibroin surfaces by phase separation

  • Original language description

    Silk protein (Bombyx mori) surfaces are characterized by poor cell adhesion, hence additional surface treatments are required in order to create structured surfaces to increase the adhesive capabilities of selected cell lines. To solve this problem, surface treatment procedures use either patterning templates or preparation of polymer blends. Phase separation procedures are rather rare. In this study, silk protein-based coatings were structured by a dropwise addition of solvent/non solvent mixtures. A special device was developed to create controlled physical conditions during the multi-step, timesequenced surface treatment. The process parameters for the surface modification were optimized to control the texture formation from nano- up to microporous structures. The interaction of different cell lines was studied on the textured surfaces to explore their application scope in biomedical applications.

  • Czech name

  • Czech description

Classification

  • Type

    O - Miscellaneous

  • CEP classification

  • OECD FORD branch

    20506 - Coating and films

Result continuities

  • Project

    Result was created during the realization of more than one project. More information in the Projects tab.

  • Continuities

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Others

  • Publication year

    2022

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů