Hierarchical nano- and microstructuring of biopolymer surfaces
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F70883521%3A28110%2F24%3A63583858" target="_blank" >RIV/70883521:28110/24:63583858 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Hierarchical nano- and microstructuring of biopolymer surfaces
Original language description
We present a novel approach to modifications of Silk protein (Bombyx mori) and hyaluronan surfaces by a solvent induced phase separation. In this research, coatings made of the biopolymers were structured using a dosed addition of solvent/non-solvent mixtures. To control the surface modification process, we developed a specialized device that allows precise setting of process parameters, such as time delays or dosing volumes of droplets. By optimizing the process parameters as well as the composition of solvent/non-solvent mixtures the formation of various nano- to microporous structures on the silk or hyaluronan surfaces have been achieved. The textures of the biomaterials coatings were significantly determined by the initial secondary conformations of the fibroin, i.e., content of beta-sheet structures or hydration of the hyaluronan surface layer. The textured silk surfaces exhibited improved properties for adhesion and proliferation of diverse cell lines, thus greatly expanding the potential applications of silk-based materials in the field of regenerative medicine. The textured hyaluronan film could be employed for the preparation of drug carriers with improved mechanical properties and accelerated solubility.
Czech name
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Czech description
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Classification
Type
O - Miscellaneous
CEP classification
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OECD FORD branch
20501 - Materials engineering
Result continuities
Project
<a href="/en/project/GA22-33307S" target="_blank" >GA22-33307S: Development of novel 3D hierarchically structured polysaccharides and proteins porous systems</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2024
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů