Preparation of silk / polycaprolactone porous scaffolds

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F70883521%3A28110%2F23%3A63571178" target="_blank" >RIV/70883521:28110/23:63571178 - isvavai.cz</a>
Alternative codes found
RIV/70883521:28610/23:63571178
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Preparation of silk / polycaprolactone porous scaffolds
Original language description
The conformational transition of the secondary structure of silk fibroin due to shear stress complicates its processability using 3D printing techniques. Therefore, mixtures of polycaprolactone (PCL) with fibroin in various solvents were prepared. From these mixtures, 3D objects were created by electrospinning and extrusion 3D printing. In case of PCL solution, the effect of used solvent and processing temperature on the formation of porous structure was observed. The arrangement of macromolecules in the printouts from fibroin with PCL solution was analyzed. Using atomic force microscopy (AFM), we observed formation of polycaprolactone spherulites which were disrupted by the incorporated fibroin in the form of nano to micro particulate structures. The organization of the lamellae of the PCL spherulites and topography of the printed structures was rearranged by phase separation process caused by poor solvent in the printing dope.
Czech name
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Czech description
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Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2023
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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