All

What are you looking for?

All
Projects
Results
Organizations

Quick search

  • Projects supported by TA ČR
  • Excellent projects
  • Projects with the highest public support
  • Current projects

Smart search

  • That is how I find a specific +word
  • That is how I leave the -word out of the results
  • “That is how I can find the whole phrase”

3D printing of silk/polycaprolactone composite scaffolds

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F70883521%3A28110%2F22%3A63557719" target="_blank" >RIV/70883521:28110/22:63557719 - isvavai.cz</a>

  • Alternative codes found

    RIV/70883521:28610/22:63557719

  • Result on the web

  • DOI - Digital Object Identifier

Alternative languages

  • Result language

    angličtina

  • Original language name

    3D printing of silk/polycaprolactone composite scaffolds

  • Original language description

    Silk protein is a biocompatible material with good mechanical properties, suitable for the development of 3D scaffolds and tissue engineering applications. The conformational transition of the secondary structure of silk fibroin due to shear stress complicates its processability using 3D printing techniques. Therefore, the solution of fibroin with polycaprolactone (PCL) in hexafluoroisopropanol as a good solvent and dimethylsulfoxid as a poor solvent were prepared. From these mixtures, 3D objects were prepared by extrusion printing and the arrangements of macromolecules in the printouts were analyzed. Using atomic force microscopy (AFM), we observed formation of polycaprolactone spherulites which were disrupted by the incorporated fibroin in the form of nano- to micro-particulate structures. The organization of the lamellae of the PCL spherulites and topography of the printed structures was rearranged by a phase separation process caused by the poor solvent in the printing dope. Resulting PCL/Fibroin scaffolds revealed good biocompatibility and mechanical stability.

  • Czech name

  • Czech description

Classification

  • Type

    O - Miscellaneous

  • CEP classification

  • OECD FORD branch

    21001 - Nano-materials (production and properties)

Result continuities

  • Project

    <a href="/en/project/GA22-33307S" target="_blank" >GA22-33307S: Development of novel 3D hierarchically structured polysaccharides and proteins porous systems</a><br>

  • Continuities

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Others

  • Publication year

    2022

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů