Morphological Characterization of Polycaprolactone Spherulites in Silk-PCL Mixtures: Implications for 3D Printing of Textured Scaffolds in Tissue Engineering

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F70883521%3A28110%2F24%3A63577618" target="_blank" >RIV/70883521:28110/24:63577618 - isvavai.cz</a>

Alternative codes found

RIV/70883521:28610/24:63577618

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Morphological Characterization of Polycaprolactone Spherulites in Silk-PCL Mixtures: Implications for 3D Printing of Textured Scaffolds in Tissue Engineering

Original language description

This study investigates the synergistic integration of silk protein and polycaprolactone (PCL) in blends derived from distinct solvents, with the primary aim of enhancing the biocompatibility of PCL and preparing a mixture suitable for 3D printing of surface-textured scaffolds.[1,2] The research explores the interaction between silk protein and PCL, revealing crucial insights into their morphological transformations and structural changes. The formation of silk protein particles in the mixture with PCL has been observed. These particles exert a profound influence on the spherulitic structure of PCL, with significant changes occurring at various concentrations. At low concentrations of silk protein, a ring-banded structure emerges, reshaping the traditional spherulites associated with PCL.[3] As the concentration of silk protein increases in the mixture, there is a gradual disappearance of spherulites, ultimately leading to the formation of a pit-patterned surface in the case of a majority contribution of silk protein in the blend. These observations underscore the influence of silk protein in modulating the surface properties of PCL blends, presenting new opportunities for tailoring material characteristics in 3D printing applications for tissue engineering.

Czech name

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Czech description

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Type

O - Miscellaneous

CEP classification

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OECD FORD branch

20505 - Composites (including laminates, reinforced plastics, cermets, combined natural and synthetic fibre fabrics; filled composites)

Project

<a href="/en/project/NU23-08-00243" target="_blank" >NU23-08-00243: Functional replacements for nerve tissue regeneration fabricated using advanced 3D printing techniques</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2024

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů