Processing of PVDF Terpolymer - Polycaprolactone Mixtures for Biomedical Applications

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F70883521%3A28110%2F24%3A63588638" target="_blank" >RIV/70883521:28110/24:63588638 - isvavai.cz</a>

Alternative codes found

RIV/70883521:28610/24:63588638

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Processing of PVDF Terpolymer - Polycaprolactone Mixtures for Biomedical Applications

Original language description

This work explores the processability of a commonly used biomaterial polycaprolactone and a synthetic poly(vi nyl idene fluoride-trifluoroethylene-ch lorotrifluoroethylene) ( PVDF-TrFE-CTFE). Polyca prolactone (PCL) is a biocompatible, biodegradable and low bioactive polymer with easy processability, making it suitable for tissue engineering and biomedical applications. (PVDF-TrFE-CTFE) is an electroactive polymer that has gained attention in the field of tissue engineering because of its unique combination of piezoelectric and ferroelectric properties. The work aimed to prepare 3D printed objects with a structured surface on the extruded fibers from PCL/PVDF-TrFE-CTFE blends. Surface texturization typically provides higher surface area which can improve cell adhesion or impact cellular morphology, both important for enhanced biocompatibility of scaffolds tissue engineering. To obtain objects with structured surfaces, a phase separation method based on the dissolution of the polymers in a combination of good and poor solvents was used. The solutions were further processed by extrusion 3D printing or electrospinning. Final fibre morphologies were analysed by microscopic methods to evaluate the effects of the solvents and process parameters on the fiber textures. Concerning the possible use of the final structures for biomedical applications, the residua! solvents in the samples were analysed by infrared spectroscopy to confirm their absence.

Czech name

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Czech description

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Type

O - Miscellaneous

CEP classification

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OECD FORD branch

10404 - Polymer science

Project

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Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2024

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů