Fine carbonyl iron particles grafted with poly(2-isopropenyl-2-oxazoline): A potential embolization agent for cancer therapy

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F70883521%3A28110%2F25%3A63592498" target="_blank" >RIV/70883521:28110/25:63592498 - isvavai.cz</a>

Alternative codes found

RIV/70883521:28610/25:63592498

Result on the web

<a href="https://www.sciencedirect.com/science/article/pii/S0169433224022633?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S0169433224022633?via%3Dihub</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.apsusc.2024.161548" target="_blank" >10.1016/j.apsusc.2024.161548</a>

Result language

angličtina

Original language name

Fine carbonyl iron particles grafted with poly(2-isopropenyl-2-oxazoline): A potential embolization agent for cancer therapy

Original language description

Despite the significant success of clinical trials on cancer patients using the therapy with carbonyl iron (CI) particles, this topic laid dormant for over two decades. In this context, we developed a CI particle-based embolization agent via polymer surface engineering and tested its biocompatibility and behavior in contact with human blood. The finest grade of the CI particles was controllably grafted with poly(2-isopropenyl-2-oxazoline) (PiPOx) using surface-initiated atom transfer radical polymerization (ATRP) to achieve a system combining the properties of suitable size, high magnetization, and advantages at the cellular level connected to the presence of PiPOx. The cell viability of 3T3 fibroblasts and P388.D1 macrophages was investigated after treatment with particle extracts and was found to be concentration-dependent but generally demonstrated no or mild cytotoxicity. The PiPOx-grafted particles showed negligible effect on the breakdown of human erythrocytes and significantly improved hydrophilic-hemophilic properties when compared to bare CI. The magnetorheological (MR) activity of the particles dispersed in human blood was studied in vitro under shear mode conditions showing slightly decreased shear stresses but improved sedimentation stability. Moreover, the effect of PiPOx molecular weight on the studied parameters was monitored across the whole range of tests. The study demonstrates the potential of prepared core-shell structures in biomedical and related fields of application.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

20501 - Materials engineering

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2025

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Applied Surface Science

ISSN

0169-4332

e-ISSN

0169-4332

Volume of the periodical

681

Issue of the periodical within the volume

1

Country of publishing house

NL - THE KINGDOM OF THE NETHERLANDS

Number of pages

12

Pages from-to

nestránkováno

UT code for WoS article

001346606200001

EID of the result in the Scopus database

2-s2.0-85206643246