Grafting of magnetic particles with poly(2-isopropenyl-2-oxazoline)
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F70883521%3A28610%2F17%3A63516726" target="_blank" >RIV/70883521:28610/17:63516726 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Grafting of magnetic particles with poly(2-isopropenyl-2-oxazoline)
Original language description
Magnetic particles play an important role in modern biomedical applications including targeted drug delivery, local embolization of blood veins, hyperthermia etc. Therefore, the development of more effective systems with high biocompatibility is of interest for many researchers. Nevertheless, these magnetic systems have to meet certain criteria necessary for in vivo applications. We have considered key requirements desired from such materials, and we have prepared a promising system based on core-shell particles via surface-initiated atom transfer radical polymerization (ATRP). The finest grade of the carbonyl iron particles was used as a suitable core and the treatment of its surface in acidic environment ensured the presence of hydroxyl groups, which were further coupled with ethoxy groups of (3-Aminopropyl)triethoxysilane. After the functionalization, the immobilization of 2-Bromoisobutyryl bromide, which served as an initiator, was performed. Finally, the initiator-treated particles were grafted with poly(2-isopropenyl-2-oxazoline) (PIPOx) under ATRP conditions as the PIPOx has recently shown a great potential in biomedical applications. The cleaning and washing procedures ensured high purity of the product. The reaction conversion, molar mass and dispersity of PIPOx grafts were investigated using nuclear magnetic resonance and gel permeation chromatography, respectively. The presence of grafted PIPOx was confirmed using Fourier-transform infrared, and energy-dispersive X-ray spectroscopies. The grafted PIPOx layer had negligible effect on particle magnetization as revealed via vibration-sample magnetometry. Synthesized core-shell structures may find utilization as a promising material for local embolization or may serve as a drug delivery system due to the presence of PIPOx bearing the active sites allowing the drug bonding.
Czech name
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Czech description
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Classification
Type
D - Article in proceedings
CEP classification
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OECD FORD branch
21001 - Nano-materials (production and properties)
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2017
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Article name in the collection
NANOCON 2017 Conference Proceedings
ISBN
978-80-87294-81-9
ISSN
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e-ISSN
neuvedeno
Number of pages
6
Pages from-to
489-494
Publisher name
Tanger Ltd.
Place of publication
Ostrava
Event location
Brno
Event date
Oct 18, 2017
Type of event by nationality
WRD - Celosvětová akce
UT code for WoS article
000452823300080