CHITOSAN-BASED COMPOSITE HYDROGELS FOR BONE TISSUE ENGINEERING

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F70883521%3A28110%2F25%3A63593318" target="_blank" >RIV/70883521:28110/25:63593318 - isvavai.cz</a>

Alternative codes found

RIV/70883521:28610/25:63593318

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

CHITOSAN-BASED COMPOSITE HYDROGELS FOR BONE TISSUE ENGINEERING

Original language description

Critical-size bone defects pose significant challenges in orthopaedics due to the limited self-healing abilities and drawbacks of autografts or allografts. This study introduces a novel approach that combines hydrogels based on dialdehyde cellulose-crosslinked water-soluble half-N-acetylated chitosan (SCN), polypyrrole (PPy) nanoparticles, and BMP-2-loaded microspheres. These hydrogels display shear-thinning behaviour, enabling minimally invasive delivery into irregular defects. In vitro and in vivo studies confirm biocompatibility, anti-inflammatory properties, and bone regeneration.

Czech name

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Czech description

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Type

O - Miscellaneous

CEP classification

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OECD FORD branch

30404 - Biomaterials (as related to medical implants, devices, sensors)

Project

<a href="/en/project/GA24-11534S" target="_blank" >GA24-11534S: Conductive (bio)polymer composites with covalently anchored polypyrrole for biomedical applications</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2025

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů