Non-toxic biodegradable polyester urethanes based on PLA
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F70883521%3A28610%2F16%3A43874604" target="_blank" >RIV/70883521:28610/16:43874604 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Non-toxic biodegradable polyester urethanes based on PLA
Original language description
Polylactide (PLA)-based polymers possess indisputable beneficial properties and they are perfectly convenient for temporary medical applications as drug carriers or resorbable supporting devices. Nevertheless, PLA is also known for its rigidity and low mechanical properties.In this research the polyethylene glycol (PEG) of various molecular weight is used for the synthesis of functionalized PLA. Functionalized polymer chains are linked by lysine ethyl ester diisocyanate to create high molecular weight polyester urethanes. The main objective of this study is to investigate physico-chemical properties, biodegradability in vitro and cytotoxicity. The results showed that the molecular weights of the products reached about 50,000 g/mol and the hydrolytic progress was rapid in the first 2 weeks; the drop in Mn equaled approximately 70%. Tensile strength testing revealed that ductility increased alongside reduced molecular weight of PEG. Cytotoxicity tests carried out according to the EN ISO 10993-5 standard revealed a moderate cytotoxic effect of polymers.
Czech name
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Czech description
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Classification
Type
O - Miscellaneous
CEP classification
CD - Macromolecular chemistry
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2016
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů