Smart polysaccharides nanoparticles for controlled release of protein

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F70883521%3A28610%2F16%3A43875560" target="_blank" >RIV/70883521:28610/16:43875560 - isvavai.cz</a>
Result on the web
—
DOI - Digital Object Identifier
—

Result language
angličtina
Original language name
Smart polysaccharides nanoparticles for controlled release of protein
Original language description
Polysaccharides based nanoparticles have been thoroughly investigated for controlled release of therapeutic molecules. The ability to regulate the release rate according to the environment at the target site represents one of the main interests in drug delivery field. The aim of this work was to prepare and characterize the pH and ionic strength sensitive chitosan-dextran sulfate based nanoparticles loaded with two model proteins, bovine serum albumin and trypsin (TRY), respectively. Nanoparticles showed size in the range 120-250 nm, positive zeta potential (20-35 mV), stability and high loading capacity, up to 800g of protein per mg of nanoparticles. The release kinetics of the both proteins was significantly influenced by the external media properties. Furthemore, the initial burst effect reduction in physiological medi was reduced.
Czech name
—
Czech description
—

Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2016
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Similar results(10)