Regioselectively oxidized hyaluronate for enhanced cisplatin delivery
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F70883521%3A28610%2F22%3A63560499" target="_blank" >RIV/70883521:28610/22:63560499 - isvavai.cz</a>
Result on the web
—
DOI - Digital Object Identifier
—
Alternative languages
Result language
angličtina
Original language name
Regioselectively oxidized hyaluronate for enhanced cisplatin delivery
Original language description
Severe side effects ofplatinum anticancer complexes led to the developrnent of various drug delivery strategies, including their conjugation to polysaccharide carriers, which offer excel!ent biocompatibility, biodegradability, and potential for targeting malignancies. However, only several polysaccharides can directly bind anticancer drugs, and these often have a low density of suitable biding groups. For instance, hyaluronate (HA) has cisplatin (CP) loading efficacy of only -50% and a loading capacity limited to 25 wt.%, because each molecule of CP requires two units of HA to bind. The resulting crosslinking also limits the conjugate solubility. Modifications aimed to improve these issues are usually centered around the COOH group of HA, which, however, impairs its ability to bind to the proteoglycan receptor CD44, thus negating one of HA's greatest advantages as a drug carrier -tumor targeťing. Hence, a sequential regioselective oxidation scheme, that introduces a pair of carboxylic groups at C2 and C3 of glucuronate has been developed and advantages of prepared 2,3-dicarboxy hyaluronate (DCH) over unmodified HA as a carrier for CP are demonstrated.The regioselective oxidation ofHA essentially triples the amount of available -COOH groups in its structure, greatly improving its capabilities as a CP carrier without modifying the N-acetyl glucosamine unit or C6 of glucuronate. DCH also possesses a large potential for further modifications.
Czech name
—
Czech description
—
Classification
Type
O - Miscellaneous
CEP classification
—
OECD FORD branch
10404 - Polymer science
Result continuities
Project
<a href="/en/project/EF16_028%2F0006243" target="_blank" >EF16_028/0006243: The Development of Capacity for Research and Development of TBU in Zlín</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2022
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů