Surface Functionalization of PLA Scaffolds with Furcellaran Derivates

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F70883521%3A28610%2F24%3A63583878" target="_blank" >RIV/70883521:28610/24:63583878 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Surface Functionalization of PLA Scaffolds with Furcellaran Derivates
Original language description
Insufficient bioactivity of poly(lactic acid) (PLA)-based scaffolds limits interactions between cells and the material, posing a challenge not only in the field of tissue engineering. This limitation can be overcome by functionalizing their surface using anionic polysaccharides similar to glycosaminoglycans, such as polysaccharides from marine algae. Therefore, the focus of this study was on creating highly porous PLA scaffolds using a solvent casting/particulate leaching method, where polyethylene glycol was used as a porogen at a mass ratio of 75%. The result was a well-connected porous structure with a thickness of 25 μm. The surface of PLA scaffolds was activated using RF plasma, followed by deposition of sulfated and carboxymethylated furcellaran with varying degrees of substitution (DS = 0.8/0.3) onto the modified surface. Identification of the sulfate/carboxymethyl groups was performed using elemental analysis and FT-IR spectroscopy. Successful surface functionalization of PLA scaffolds was confirmed by SEM and XPS analyses, which showed changes in topography and increased characteristic elements (N, S, Na) for surfaces treated with sulfated (SF) and carboxymethylated (CMF) furcellaran. Cytocompatibility was assessed using a mouse embryonic fibroblast cell line (NIH/3T3).
Czech name
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Czech description
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Publication year
2024
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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