Bacterial cellulose/graphene oxide/hydroxyapatite biocomposite: A scaffold from sustainable sources for bone tissue engineering
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F70883521%3A28610%2F25%3A63593038" target="_blank" >RIV/70883521:28610/25:63593038 - isvavai.cz</a>
Result on the web
<a href="https://pubs.acs.org/doi/10.1021/acsami.4c17306" target="_blank" >https://pubs.acs.org/doi/10.1021/acsami.4c17306</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1021/acsami.4c17306" target="_blank" >10.1021/acsami.4c17306</a>
Alternative languages
Result language
angličtina
Original language name
Bacterial cellulose/graphene oxide/hydroxyapatite biocomposite: A scaffold from sustainable sources for bone tissue engineering
Original language description
Bone tissue engineering demands advanced biomaterials with tailored properties. In this regard, composite scaffolds offer a strategy to integrate the desired functionalities. These scaffolds are expected to provide sufficient cellular activities while maintaining the required strength necessary for the bone repair for which they are intended. Hence, attempts to obtain efficient composites are growing. However, in most cases, the conventional production methods of scaffolds are energy-intensive and leave an impact on the environment. This work aims to develop a biocomposite scaffold integrating bacterial cellulose (BC), hydroxyapatite (HAp), and graphene oxide (GO), designated as “BC/HAp/GO”. All components are sourced primarily from agricultural and food waste as alternative means. BC, known for its biocompatibility, fine fiber network, and high porosity, serves as an ideal scaffold material. HAp, a naturally occurring bone component, contributes osteoconductive properties, while GO provides mechanical strength and biofunctionalization capabilities. The biomaterials were analyzed and characterized using a scanning electron microscope, a X-ray diffractometer, and a Fourier transform infrared spectrometer. The produced biocomposite scaffolds were tested for thermal stability, mechanical strength, and biocompatibility. The results showed a nanofibrous, porous network of BC, highly crystalline HAp particles, and well-oxygenated GO flakes with slight structural deformities. The synthesized biocomposite demonstrated promising characteristics, such as increased tensile strength due to added GO particles and higher bioactivity through the introduction of HAp. These inexpensively synthesized materials, marked by suitable surface morphology and cell adhesion properties, open potential applications in bone repair and regeneration.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10620 - Other biological topics
Result continuities
Project
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Continuities
S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2025
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
ACS Applied Materials and Interfaces
ISSN
1944-8244
e-ISSN
1944-8252
Volume of the periodical
17
Issue of the periodical within the volume
1
Country of publishing house
US - UNITED STATES
Number of pages
11
Pages from-to
572-582
UT code for WoS article
001380415600001
EID of the result in the Scopus database
2-s2.0-85212658559